ABOUT US

NFKB SIGNALING IN HUMAN AILMENTS

Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, it is now known that when allowed to continue unchecked, chronic inflammation is a key underlying cause for the development of autoimmune disorders, neurodegenerative diseases, metabolic syndromes such as diabetes and cancer. Our lab studies a transcription factor called NFkB which is a master regulator of inflammation. Indeed deregulated activity of NFkB precedes and is causally linked to chronic inflammation and the development of several human ailments including metabolic syndromes and cancers. However, given that NFkB signaling is also essential for many housekeeping cellular and developmental events in normal human beings, simply blocking NFkB B to curb inflammation is not an option. Hence deciphering the regulation of NFkB signaling is crucial to understanding the mechanism and role of uncontrolled/unwanted NFkB activity seen in human ailments and in developing better and safer anti-inflammatory drug. We are focusing and our efforts to identify targets that will help develop drugs which will block NFkB /inflammation more selectively and not generically and hence may have less side effects.

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Prospective Graduate Students/ interns can indicate Prof Vinay Tergaonkar as their choice lab/ PI.

Prospective Graduate Students:
The Singapore International Graduate Award (SINGA)
Upon successful completion, students will be conferred a PhD degree by either NTU, NUS, SUTD or SMU. Please click here for further details.


Prospective Interns:
The A*STAR Research Attachment Programme (ARAP) is a collaboration between A*STAR and partner universities to provide research opportunities for PhD students at A*STAR Research Institutes. Under this programme, PhD students from overseas universities will spend a minimum of one to a maximum of two years at A*STAR Research Institutes under the joint supervision of staff of the A*STAR Research Institutes and the overseas universities. Please click here for further details.


The Singapore International Pre-Graduate Award (SIPGA) supports short-term research attachments for international students at A*STAR. It provides a unique opportunity for top overseas students to experience the vibrant scientific environment in A*STAR Research Institutes and Consortia. Students will be able to work with distinguished and world-renowned researchers in A*STAR labs. This award will normally be for students in the later years of a Bachelor or Master level program. Students considering PhD studies in A*STAR are encouraged to apply. Please click here for further details.


The A*STAR Research Internship Award (ARIA) offers curated research-based internship opportunities at the A*STAR Research Institutes (RIs) to Singaporean Science, Technology, Engineering and Mathematics (STEM) undergraduates in universities. Please click here for further details.